Chiral separation of propranolol enantiomers

Racemic Propranolol is a medication of the beta-blocker type very useful to treat cardiovascular diseases. The S(-)-enantiomer is approximately 100 times more active and metabolized 100 times slower than the R(-)-enantiomer. In this application note, the Wyn-CE system is used to carry out the chiral separation of Propranolol.

L'avis de l'expert : Capillary electrophoresis is a useful and efficient technique for chiral analysis.

Réactifs et conditions d'analyse

Tampon : Phosphate + ethanolamine + CD, pH 3.0
Capillaire : bare-fused silica, L = 35 cm, l = 27 cm, ID = 50 µm
Injection : hydrodynamic, 50 mbar, 5 s
Tension : +20 kV
Détection : UV, 214 nm
Température : 25 °C


Other applications Pharmaceutical quality control

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